Modeling R8 Specification in the Drosophila Eye ebook

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Author: Jennifer S Hammond
Published Date: 08 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Book Format: Paperback::222 pages
ISBN10: 1243732458
Publication City/Country: Charleston SC, United States
File size: 28 Mb
Dimension: 189x 246x 12mm::404g
Download Link: Modeling R8 Specification in the Drosophila Eye
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Modeling R8 Specification in the Drosophila Eye ebook. We have reexamined the role of Rap in Drosophila eye development and found that it is critically required along with Ras to specify the R7 precursor as a photoreceptor. The other photoreceptors do not require Rap for their specification, and we correlate the requirement for Rap with the level of N activity in the photoreceptor precursors: R7 (high N activity) requires Rap, and the other Laden Sie kostenlos Lehrbücher herunter Modeling R8 Specification in the Drosophila Eye 1243732458 Jennifer S Hammond, Matthew W Pennington PDF. R8 photoreceptors are specified in a precise hexagonal pattern behind an advancing front as it traverses the eye imaginal disc during extitDrosophila development. In an attempt to better understand this patterning event, we have developed a mathematical model consisting of coupled differential equations on a lattice incorporating auto factor Erect wing regulates specification and maintenance of Drosophila R8 context, in the Drosophila eye for the robust specification of R8 photoreceptor neuron to Clear Mutant Rhodopsin-1 in Drosophila Retinitis Pigmentosa Models. Cell fate specification in the Drosophila compound eye appears to be mediated signals from neighboring cells within each developing cluster of cells in the eye-imag- inal disc (for review, see Greenwald and Rubin 1992). A rapidly growing number of genes required in photorecep- tor cell determination, particularly that of the R7 cell, have been identified. These include sevenless (sev atonal (ato) encodes a basic helix loop helix protein and is required for the specification of R8 photoreceptor cells in Drosophila. In the eye imaginal discs, expression of Ato protein is initially in a dorsoventral stripe of cells anterior to the morphogenetic furrow (MF). In the furrow, single precisely spaced cells are specified to become the first retinal neural cell type: the R8 photoreceptor cell. This Drosophila founder cell specification is coincident with and dependant upon the expression of the fly Ath5 ortholog: Atonal. Indeed, in both taxa, the process of founder cell specification may be viewed as the regulation of Atonal expression. It is now clear The Drosophila retina contains about 800 repeating unit eyes called ommatidia, each with 8 photoreceptors (Hardie, 1985). There are two main subtypes of ommatidia which are defined the expression of Rhodopsin proteins in the color-detecting inner photoreceptors, R7 and R8 (Rister et al., 2013). In pale (p) Drosophila melanogaster, the fruit fly, has compound eyes consisting of around 750 Modeling R8 Specification in the Drosophila Eye, from Genes to Tissue. R8 photoreceptors are specified in a precise hexagonal pattern behind an advancing front as it traverses the eye imaginal disc during Drosophila development. In an attempt to better understand this patterning event, we have developed a mathematical model consisting of coupled differential equations on a lattice incorporating auto-activation The Drosophila compound eye is composed of ~750 unit eyes called (B) Regulatory network controlling R7 and R8 fate specification. To distinguish between the two models, we sought to identify the origin of the distinct The fruit fly Drosophila melanogaster has several different ommatidium However, despite the detailed understanding of ommatidia specification in D. Compound eye structure is best understood in the model (R7 and R8) with R7 located closest to the outer surface of the eye, on top of R8 (Figure 1). Modeling R8 Specification in the Drosophila Eye, from Genes to Tissue Matthew W. Pennington A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Biophysics) in The University of Michigan 2009 Doctoral Committee: Assistant Professor David The Drosophila compound eye is composed of 750 ommatidia, each consisting of eight photoreceptor cells, R1 R8, four cone cells, and several other accessory cells (1). In the third-instar larvae, neuronal differentiation of the retina is initiated at the most posterior tip of the eye imaginal disc and progresses The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. Start studying Lecture 15 - Drosophila eye development. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Many R7 and R8 cells exhibit axonal sprouting while some show cell degeneration. Drosophila has proven to be a valuable genetic model to investigate the roles controlling cell specification and differentiation (Treisman, 2013). These flies exhibited an external eye morphology similar to control flies R8 development in the Drosophila eye: a paradigm for neural selection and differentiation Development,Mar 2002 Benjamin J. Frankfort,Graeme Mardon Understanding the regulatory logic that allows intercellu- transcription factor, Atonal, upon which R8 specification lar signaling to define complex patterns is one of the depends [4, 5]. Atonal is first expressed in a uniform band prime goals of developmental biology. The Drosophila eye of cells ahead of the furrow; at the posterior edge of the Modeling R8 Specification in the Drosophila Eye, from Genes to Tissue. Matthew W. Pennington. Abstract. Drosophila melanogaster, the fruit fly, has compound eyes consisting of around 750 facets called ommatidia, arranged in a regular hexagonal grid. Each facet is centered on a suite of 8 photoreceptor neurons (R1-R8), of which R8 is the first retinal cell to attain a specific fate. In this

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